ISOLATION AND IDENTIFICATION OF BETA-HYDROXYETHYLAPROPHEN - A URINARY METABOLITE OF APROPHEN IN RATS

被引：1

作者：

BROWN, ND ^{[1
]}

PHILLIPS, LR ^{[1
]}

LEADER, H ^{[1
]}

CHIANG, PK ^{[1
]}

机构：

[1] US FDA,DIV BIOCHEM & BIOPHYS,BETHESDA,MD 20892

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 563卷 / 02期

关键词：

D O I：

10.1016/0378-4347(91)80057-J

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The metabolism of the anticholinergic drug aprophen was studied in rats after oral administration via stomach intubation. Beta-Hydroxyethylaprophen, a major urinary metabolite of aprophen, was isolated and identified by normal-phase high-performance liquid chromatography and electron ionization mass spectrometry. More than 22% of the parent drug was recovered and quantified over a 72-h collection period. Results show that 2,2-diphenylpropionic acid, another major metabolite of aprophen which lacks anti-cholinergic properties, was also isolated and identified in this study. Experiments are currently underway to synthesize and test the anticholinergic properties of beta-hydroxyethylaprophen in mammals.

引用

页码：466 / 471

页数：6

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