ISOLATION AND IDENTIFICATION OF BETA-HYDROXYETHYLAPROPHEN - A URINARY METABOLITE OF APROPHEN IN RATS

被引:1
|
作者
BROWN, ND [1 ]
PHILLIPS, LR [1 ]
LEADER, H [1 ]
CHIANG, PK [1 ]
机构
[1] US FDA,DIV BIOCHEM & BIOPHYS,BETHESDA,MD 20892
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 563卷 / 02期
关键词
D O I
10.1016/0378-4347(91)80057-J
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The metabolism of the anticholinergic drug aprophen was studied in rats after oral administration via stomach intubation. Beta-Hydroxyethylaprophen, a major urinary metabolite of aprophen, was isolated and identified by normal-phase high-performance liquid chromatography and electron ionization mass spectrometry. More than 22% of the parent drug was recovered and quantified over a 72-h collection period. Results show that 2,2-diphenylpropionic acid, another major metabolite of aprophen which lacks anti-cholinergic properties, was also isolated and identified in this study. Experiments are currently underway to synthesize and test the anticholinergic properties of beta-hydroxyethylaprophen in mammals.
引用
收藏
页码:466 / 471
页数:6
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