CHROMATOGRAPHIC-SEPARATION OF THE OPTICAL ISOMERS OF NAPROXEN

被引：19
|
作者：
KERN, JR
机构：
[1] Analytical and Environmental Research Laboratory, Syntex Research, Palo Alto, CA 94304
来源：
JOURNAL OF CHROMATOGRAPHY | 1991年 / 543卷 / 02期
关键词：
D O I：
10.1016/S0021-9673(01)95787-5
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Naproxen, (S)-6-methoxy-alpha-methyl-2-naphthyleneacetic acid, is a non-steroidal anti-inflammatory drug, which is administered as a single enantiomer. Two different approaches applying high-performance liquid chromatography for the determination of the optical purity of naproxen are described. One method involves the derivatization of naproxen with 3,5-dinitroaniline and separation of the amide derivatives on a (R)-N-(2-naphtyl)alanine chiral stationary phase. The second method is a direct separation of naproxen optical isomers using alpha-1-acid glycoprotein columns. The latter method has been studied in detail to address the effects of temperature, ionic strength, pH and concentration of mobile phase buffer on enantiomeric resolution.
引用
收藏
页码：355 / 366
页数：12
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