HETEROGENEITY OF GABA(A)-RECEPTORS - CELL-SPECIFIC EXPRESSION, PHARMACOLOGY, AND REGULATION

被引：67
|
作者：
MOHLER, H [1 ]
KNOFLACH, F [1 ]
PAYSAN, J [1 ]
MOTEJLEK, K [1 ]
BENKE, D [1 ]
LUSCHER, B [1 ]
FRITSCHY, JM [1 ]
机构：
[1] ETH ZURICH,CH-8057 ZURICH,SWITZERLAND
来源：
NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 05期
关键词：
GAMMA-AMINOBUTYRIC ACID; INHIBITORY NEUROTRANSMISSION; BENZODIAZEPINE RECEPTORS; RECEPTOR SUBUNIT; GENE REGULATION; NEURON-SPECIFIC EXPRESSION;
D O I：
10.1007/BF01694546
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABA(A)-receptor function. A multitude of different GABA(A)-receptors exist in the brain due to the combinatorial assembly Of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABA(A)-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.
引用
收藏
页码：631 / 636
页数：6
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