NONPARAMETRIC-ESTIMATION OF POTENCY RATIO FOR DILUTION ASSAYS

被引：0
|
作者：
MOUSSA, MAA
机构：
[1] Department of Community Medicine, Faculty of Medicine and Health Sciences, Al-Ain
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 1993年 / 23卷 / 01期
关键词：
DILUTION ASSAYS; MONOTONE DOSAGE RESPONSE CURVES; NONPARAMETRIC METHODS; POTENCY RATIO; MANTEL-HAENSZEL TEST;
D O I：
10.1016/0010-4825(93)90110-M
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The paper considers the estimation of the potency of an unknown test preparation in relation to a standard in a dilution assay. The method utilizes the Mantel-Haenszel one degree of freedom chi-square approach to test consistency of the observed potency ratio with a range of alternative potency ratios. The method is nonparametric as it does not require any distributional assumptions. However, it requires the doses employed to be equally spaced logarithmically. The dose-response curve is also required to be monotone over the dose range used.
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页码：77 / 82
页数：6
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