ROLE OF THE CDC8 GENE IN THE REPAIR OF SINGLE-STRAND BREAKS IN DNA OF THE YEAST SACCHAROMYCES-CEREVISIAE

被引：3
|
作者：
BARANOWSKA, H
ZABOROWSKA, D
JACHYMCZYK, WJ
ZUK, J
机构：
[1] Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, PL-02-532
来源：
CURRENT GENETICS | 1990年 / 18卷 / 03期
关键词：
CDC8; gene; DNA repair;
D O I：
10.1007/BF00318376
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
It has been found that the repair of single strand breaks is defective in the DNA replication mutants cdc8-1 and cdc8-3 of Saccharomyces cerevisiae both in permissive (23°C) and restrictive conditions (36°C). In permissive conditions we observed a significant delay in single strand break repair in a diploid strain HB7 (cdc8-1/cdc8-1), as compared with the wild-type strain. Under restrictive conditions no repair was observed, but rather degradation of MMS-damaged DNA occurred. It has been also found that the repair of single strand breaks in yeast is inhibited by cycloheximide but not by hydroxyurea. © 1990 Springer-Verlag.
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页码：175 / 179
页数：5
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