INFLUENCE OF NOCLOPROST ON THE VASCULAR-RESPONSES TO VARIOUS STIMULI IN THE ISOLATED PERFUSED RABBIT KIDNEY

被引：0
|
作者：
ERCAN, ZS [1 ]
TURKER, R [1 ]
机构：
[1] UNIV ANKARA,FAC MED,DEPT PHARMACOL,ANKARA,TURKEY
来源：
EXPERIENTIA | 1991年 / 47卷 / 01期
关键词：
NOCLOPROST; RABBIT KIDNEY; ANGIOTENSIN-II; NORADRENALINE; SYMPATHETIC STIMULATION;
D O I：
10.1007/BF02041256
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nocloprost, a new synthetic prostanoid, elicited a vasodilator action when given through the renal artery of the isolated perfused rabbit kidney. Lower concentrations of the compound inhibited the pressor response to sympathetic stimulation or to angiotensin II, but potentiated the pressor effect of exogenous noradrenaline. These results were taken as an evidence that nocloprost prevents the release of neurotransmitter by a presynaptic mechanism.
引用
收藏
页码：69 / 70
页数：2
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