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Univ Milan, Pediat Highly Intens Care Unit, Dept Pathophysiol & Transplantat, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via Commenda 9, I-20122 Milan, Italy Univ Milan, Pediat Highly Intens Care Unit, Dept Pathophysiol & Transplantat, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via Commenda 9, I-20122 Milan, Italy