CHARACTERIZATION OF THE PROMOTER REGION OF HUMAN BCL-6 GENE

被引：22
|
作者：
OHASHI, K [1 ]
MIKI, T [1 ]
HIROSAWA, S [1 ]
AOKI, N [1 ]
机构：
[1] TOKYO MED & DENT UNIV,DEPT INTERNAL MED 1,BUNKYO KU,TOKYO 113,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 02期
关键词：
D O I：
10.1006/bbrc.1995.2309
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The BCL-6 gene encodes a zinc finger-transcription factor and frequently is rearranged in diffuse large cell lymphoma. We have reported here the isolation of the 5'-flanking region of the human BCL-6 gene. Nucleotides sequence of 1.5 Kb promoter region contains TATA box but no CAAT box and a number of potential regulatory elements including CACCC, E-box, and GATA-1 sites. Studies of the promoter activity showed the first 657 nucleotides of the 5'-flanking region significantly drove transcription of the luciferase reporter gene in human Burkitt's lymphoma cell line. (C) 1995 Academic Press, Inc.
引用
收藏
页码：461 / 467
页数：7
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