ENHANCEMENT OF THE ANTI-HIV-1 ACTIVITY OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE (D4T) BY THE THYMIDYLATE SYNTHETASE INHIBITOR FUDR - AN ANTI-HIV STRATEGY WITH A HOST-CELL TARGET

被引:0
|
作者
GAO, WY
JOHNS, DG
AHLUWALIA, G
MITSUYA, H
机构
[1] NCI,DTP,MED CHEM LAB,BETHESDA,MD 20892
[2] NCI,DTP,MED BRANCH,EXPTL RETROVIROL SECT,BETHESDA,MD 20892
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:S161 / S161
页数:1
相关论文
共 50 条
  • [41] 5-CHLORO-SUBSTITUTED DERIVATIVES OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYURIDINE, 3'-FLUORO-2',3'-DIDEOXYURIDINE AND 3'-AZIDO-2',3'-DIDEOXYURIDINE AS ANTI-HIV AGENTS
    BALZARINI, J
    VANAERSCHOT, A
    HERDEWIJN, P
    DECLERCQ, E
    BIOCHEMICAL PHARMACOLOGY, 1989, 38 (06) : 869 - 874
  • [42] SYNTHESIS AND EVALUATION OF ANTI-HIV-1 AND ANTITUMOR-ACTIVITY OF 2',3'-DIDEHYDRO-2',3'-DIDEOXY-3-DEAZAADENOSINE, 2',3'-DIDEOXY-3-DEAZAADENOSINE AND SOME 2',3'-DIDEOXY-3-DEAZAADENOSINE 5'-DIALKYL PHOSPHATES
    FRANCHETTI, P
    CAPPELLACCI, L
    CRISTALLI, G
    GRIFANTINI, M
    PANI, A
    LACOLLA, P
    NOCENTINI, G
    NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (07): : 1551 - 1562
  • [43] Synthesis of a highly active new anti-HIV agent 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine
    Haraguchi, K
    Takeda, S
    Tanaka, H
    Nitanda, T
    Baba, M
    Dutschman, GE
    Cheng, YC
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (21) : 3775 - 3777
  • [44] ANTI-HIV-1 ACTIVITY OF 2',3'-DIDEOXYNUCLEOSIDE ANALOGS - STRUCTURE-ACTIVITY RELATIONSHIP
    DECLERCQ, E
    VANAERSCHOT, A
    HERDEWIJN, P
    BABA, M
    PAUWELS, R
    BALZARINI, J
    NUCLEOSIDES & NUCLEOTIDES, 1989, 8 (5-6): : 659 - 671
  • [45] Synthesis, in vitro biological stability, and anti-HIV activity of 5-halo (or methoxy)-6-alkoxy (azido or hydroxy)-5,6-dihydro-2',3'-didehydro-3'-deoxythymidin diastereomers as potential prodrugs of 2',3'-didehydro-3'-deoxythymidine (D4T)
    Kumar, R
    Wang, LL
    Wiebe, LI
    Knaus, EE
    NUCLEOSIDES & NUCLEOTIDES, 1996, 15 (1-3): : 265 - 286
  • [46] Synthesis and anti-HIV activity of some S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of 3′-azido-2′,3′-dideoxythymidine
    Egron, D
    Périgaud, C
    Gosselin, G
    Aubertin, AM
    Imbach, JL
    NUCLEOSIDES & NUCLEOTIDES, 1999, 18 (4-5): : 981 - 982
  • [47] Synthesis and anti-HIV activity of [D4U]-[Trovirdine analogue] and [D4T]-[Trovirdine analogue] heterodimers as inhibitors of HIV-1 reverse transcriptase
    Gavriliu, D
    Fossey, C
    Ciurea, A
    Delbederi, Z
    Sugeac, E
    Ladurée, D
    Schmidt, S
    Laumond, G
    Aubertin, AM
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2002, 21 (8-9): : 505 - 533
  • [48] Synthesis and Anti-HIV Activity of 5′-Homo-2′,3′-dideoxy-2′,3′-didehydro-4′-selenonucleosides (5′-Homo-4′-Se-d4Ns)
    Qu, Shuhao
    Kim, Gyudong
    Yu, Jinha
    Sahu, Pramod K.
    Choi, Yoojin
    Naik, Siddhi D.
    Jeong, Lak Shin
    ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 5 (06) : 735 - 741
  • [49] CELL SPECIES-DEPENDENT METABOLISM OF THE POTENT ANTI-HIV (HUMAN IMMUNODEFICIENCY VIRUS) COMPOUNDS 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE AND 2',3'-DIDEOXYCYTIDINE
    BALZARINI, J
    DECLERCQ, E
    BRODER, S
    JOHNS, DG
    PEDIATRIC RESEARCH, 1988, 24 (01) : 112 - 112
  • [50] Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2′,3′-dideoxy-2′,2′-difluoro-4′-azanucleosides
    Martinez-Montero, Saul
    Fernandez, Susana
    Sanghvi, Yogesh S.
    Theodorakis, Emmanuel A.
    Detorio, Mervi A.
    Mcbrayer, Tamara R.
    Whitaker, Tony
    Schinazi, Raymond F.
    Gotor, Vicente
    Ferrero, Miguel
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (23) : 6885 - 6893