FALSE-POSITIVE AND FALSE-NEGATIVE RATES IN MECONIUM DRUG-TESTING

被引：0

作者：

MOORE, C ^{[1
]}

LEWIS, D ^{[1
]}

LEIKIN, J ^{[1
]}

机构：

[1] RUSH PRESBYTERIAN ST LUKES MED CTR,RUSH POISON CONTROL CTR,CHICAGO,IL 60612

来源：

CLINICAL CHEMISTRY | 1995年 / 41卷 / 11期

关键词：

GAS CHROMATOGRAPHY MASS SPECTROMETRY; PEDIATRIC CLINICAL CHEMISTRY; DRUG METABOLITES; SOLVENT EXTRACTION; SOLID-PHASE EXTRACTION;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

To determine the number of false-negative results produced by inefficient extraction of drugs from meconium, three published procedures were compared by using previously confirmed positive and negative meconium specimens, The methods were not equivalent in their ability to extract drugs from the matrix, To determine the number of false positives reported by the use of screen-only (unconfirmed) results, 535 screen-positive meconium specimens were subjected to confirmation by gas chromatography-mass spectrometry. Fifty-seven percent of the samples were confirmed positive for one or more of the drugs under investigation, showing that a false-positive rate as high as 43% may exist when unconfirmed screening results are used.

引用

页码：1614 / 1616

页数：3

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