RAPID-DETERMINATION OF SPARTEINE AND ITS METABOLITES IN URINE

被引：2

作者：

VENINGEROVA, M ^{[1
]}

PRACHAR, V ^{[1
]}

LUKACSOVA, M ^{[1
]}

GLASA, J ^{[1
]}

HOLOMAN, J ^{[1
]}

机构：

[1] POSTGRAD MED INST,DEPT CLIN PHARMACOL,CS-83302 BRATISLAVA,SLOVAKIA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 622卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80277-B

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method is presented for the isolation, separation and determination of sparteine and its metabolites in urine. The isolation is based on rapid extraction with dichloromethane and pentane in a glass separator. For the separation and determination, capillary gas chromatography with nitrogen-phosphorus detection was used. The recovery of the method ranged from 81.6% to 94.8%, and the limit of determination varied between 0.2 and 0.5 mu g ml(-1). For quantification, 17-ethylsparteine was used as the internal standard.

引用

页码：274 / 277

页数：4

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