WHICH POLYMERS CAN MAKE NANOPARTICULATE DRUG CARRIERS LONG-CIRCULATING

被引:364
|
作者
TORCHILIN, VP [1 ]
TRUBETSKOY, VS [1 ]
机构
[1] HARVARD UNIV,SCH MED,BOSTON,MA 02129
关键词
LONG-CIRCULATING DRUG CARRIERS; LIPOSOMES; NANOPARTICLES; POLY(ETHYLENE GLYCOL); AMPHIPHILIC FLEXIBLE POLYMERS; POLYMER CONFORMATIONS;
D O I
10.1016/0169-409X(95)00022-Y
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The protective effect of poly(ethylene glycol) and some other polymers on nanoparticulate carriers including liposomes is considered in terms of statistical behavior of macromolecules in solution, when polymer flexibility plays a key role. According to the mechanism proposed, surface-grafted chains of flexible and hydrophilic polymers form dense ''conformational clouds'' preventing other macromolecules from the interaction with the surface even at low concentration of protecting polymer. Using liposomes as an example, experimental evidence is presented of the importance of protecting polymer flexibility in liposome steric protection. Further possible applications of the suggested model are discussed. The possibility of using protecting polymers other than poly(ethylene glycol) is analyzed, and examples of such polymers are given based on polymer-coated liposome biodistribution data. General requirements for protecting polymers are formulated, and differences in steric protection of liposomes and particles are discussed. The scale of protective effect is interpreted as the balance between the energy of hydrophobic anchor interaction with the liposome membrane core or with the particle surface and the energy of polymer chain free motion in solution.
引用
收藏
页码:141 / 155
页数:15
相关论文
共 50 条
  • [31] pH-sensitive, serum-stable and long-circulating liposomes as a new drug delivery system
    Hong, MS
    Lim, SJ
    Oh, YK
    Kim, CK
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2002, 54 (01) : 51 - 58
  • [32] Long-Circulating Heparin-Functionalized Magnetic Nanoparticles for Potential Application as a Protein Drug Delivery Platform
    Zhang, Jian
    Shin, Meong Cheol
    David, Allan E.
    Zhou, Jie
    Lee, Kyuri
    He, Huining
    Yang, Victor C.
    MOLECULAR PHARMACEUTICS, 2013, 10 (10) : 3892 - 3902
  • [33] Development of Long-Circulating Zwitterionic Cross-Linked Micelles for Active-Targeted Drug Delivery
    Lin, Weifeng
    Ma, Guanglong
    Kampf, Nir
    Yuan, Zhefan
    Chen, Shengfu
    BIOMACROMOLECULES, 2016, 17 (06) : 2010 - 2018
  • [34] Serum-stable, long-circulating paclitaxel-loaded colloidal carriers decorated with a new amphiphilic PEG derivative
    Basile, Livia
    Passirani, Catherine
    Ngoc-Trinh Huynh
    Bejaud, Jerome
    Benoit, Jean-Pierre
    Puglisi, Giovanni
    Pignatello, Rosario
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 426 (1-2) : 231 - 238
  • [35] The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers
    Fan, Wufa
    Peng, Haixia
    Yu, Zhou
    Wang, Luting
    He, Haisheng
    Ma, Yuhua
    Qi, Jianping
    Lu, Yi
    Wu, Wei
    ACTA PHARMACEUTICA SINICA B, 2022, 12 (05) : 2479 - 2493
  • [36] Surface Modification with Alginate-Derived Polymers for Stable, Protein-Repellent, Long-Circulating Gold Nanoparticles
    Kodiyan, Anu
    Silva, Eduardo A.
    Kim, Jaeyun
    Aizenberg, Michael
    Mooney, David J.
    ACS NANO, 2012, 6 (06) : 4796 - 4805
  • [37] The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers
    Wufa Fan
    Haixia Peng
    Zhou Yu
    Luting Wang
    Haisheng He
    Yuhua Ma
    Jianping Qi
    Yi Lu
    Wei Wu
    Acta Pharmaceutica Sinica B, 2022, 12 (05) : 2479 - 2493
  • [38] Screening of pH-responsive long-circulating polysaccharide-drug conjugate nanocarriers for antitumor applications
    Zhang, Xinyu
    Li, Dandan
    Huang, Jun
    Ou, Kunyong
    Yan, Binyuan
    Shi, Fu
    Zhang, Jiayuan
    Zhang, Junfu
    Pang, Jun
    Kang, Yang
    Wu, Jun
    JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (02) : 251 - 264
  • [39] Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications
    Rahmani, Sahar
    Villa, Carlos H.
    Dishman, Acacia F.
    Grabowski, Marika E.
    Pan, Daniel C.
    Durmaz, Hakan
    Misra, Asish C.
    Colon-Melendez, Laura
    Solomon, Michael J.
    Muzykantov, Vladimir R.
    Lahann, Joerg
    JOURNAL OF DRUG TARGETING, 2015, 23 (7-8) : 750 - 758
  • [40] PEG/heparin-decorated lipid-polymer hybrid nanoparticles for long-circulating drug delivery
    Sheng, Yan
    Chang, Lingqian
    Kuang, Tairong
    Hu, Jiaming
    RSC ADVANCES, 2016, 6 (28): : 23279 - 23287