ANTIDIABETIC SULFONYLUREAS RELAX ISOLATED RABBIT CORONARY-ARTERIES

被引：11
|
作者：
NIELSENKUDSK, JE
THIRSTRUP, S
机构：
[1] Institute of Pharmacology, University of Aarhus, DK-8000 Aarhus C, The Bartholin Building
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 03期
关键词：
SULFONYLUREAS; GLIBENCLAMIDE; CROMAKALIM; K+ CHANNELS; CORONARY ARTERY; SMOOTH MUSCLE;
D O I：
10.1016/0014-2999(91)90182-P
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Antidiabetic sulfonylureas completely relaxed isolated rabbit coronary arteries contracted by prostaglandin F2-alpha. The order of potency was glibenclamide (EC50 = 4.75-mu-M) > glipizide = glibornuride = tolbutamide = chlorpropamide. The drugs also relaxed the contractions induced by 30 mM K+ but much less potently. The effectiveness of the drugs as vascular smooth muscle relaxants did not correlate with their ability to antagonize the vasorelaxant action of cromakalim. Sulfonylurea-induced vasorelaxation probably involves mechanisms other than an interaction with ATP-regulated K+ channels.
引用
收藏
页码：273 / 275
页数：3
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