CLONING OF THE BETA-CELL HIGH-AFFINITY SULFONYLUREA RECEPTOR - A REGULATOR OF INSULIN-SECRETION

被引：1193
作者：
AGUILARBRYAN, L
NICHOLS, CG
WECHSLER, SW
CLEMENT, JP
BOYD, AE
GONZALEZ, G
HERRERASOSA, H
NGUY, K
BRYAN, J
NELSON, DA
机构：
[1] BAYLOR COLL MED, DEPT MED, HOUSTON, TX 77030 USA
[2] WASHINGTON UNIV, SCH MED, DEPT CELL BIOL, ST LOUIS, MO 63110 USA
[3] WASHINGTON UNIV, SCH MED, DEPT PHYSIOL, ST LOUIS, MO 63110 USA
来源：
SCIENCE | 1995年 / 268卷 / 5209期
关键词：
D O I：
10.1126/science.7716547
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic beta cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (K-ATP) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect K-ATP channel activity, and thereby modulate insulin release.
引用
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页码：423 / 426
页数：4
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