PUMILACIDIN, A COMPLEX OF NEW ANTIVIRAL ANTIBIOTICS - PRODUCTION, ISOLATION, CHEMICAL-PROPERTIES, STRUCTURE AND BIOLOGICAL-ACTIVITY

被引：107
|
作者：
NARUSE, N
TENMYO, O
KOBARU, S
KAMEI, H
MIYAKI, T
KONISHI, M
OKI, T
机构：
[1] Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku
来源：
JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 03期
关键词：
D O I：
10.7164/antibiotics.43.267
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a β-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamic acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K+-ATPase and demonstrated antiulcer activity in rat. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
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页码：267 / 280
页数：14
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