STRUCTURAL OPTIMIZATION OF ALKYL-SUBSTITUTED 2-(7-5H-[1]BENZOPYRANO[2,3-B]PYRIDYL)PROPIONIC ACID AS ANTIINFLAMMATORY AGENTS

被引：1
|
作者：
NAKA, Y
YAMADA, I
OCHI, H
MATSUURA, M
NAGAMATSU, Y
OE, T
机构：
[1] Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd. 955 Koiwai, Chikujo-gun, Fukuoka, 871, Yoshitomi-cho
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 09期
关键词：
D O I：
10.1016/0960-894X(95)00141-F
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several alkyl-analogues of pranoprofen were synthesized and their cyclooxygenase inhibitory activities were evaluated in a screening test. The chosen compounds were analyzed on the relationships between structure, lipophilicity (log P) and cell binding affinity. 2-Methyl analogue (4b) was confirmed to be an optimal compound in this series.
引用
收藏
页码：959 / 962
页数：4
相关论文
共 50 条
  • [21] FACILE SYNTHESIS OF 5H-[1]BENZOPYRANO[2,3-B]-1,2,3,4-TETRAHYDROPYRIDIN-5-ONES
    PASUTTO, FM
    ABUZAR, S
    SATYAMURTHY, S
    HETEROCYCLES, 1985, 23 (09) : 2293 - 2297
  • [22] SYNTHESIS OF (3-CARBOXY-5-OXO-5H-[1]BENZOPYRANO[2,3-B]PYRIDIN-2-YL)ACETIC ACID-DERIVATIVES, POTENTIAL ANTIARTHRITIC AGENTS
    KUBO, K
    UKAWA, K
    KUZUNA, S
    NOHARA, A
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1986, 34 (03) : 1108 - 1117
  • [23] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SUBSTITUTED PHTHALAZINO[2,3-B]PHTHALAZINE-5(7H)-12(14H)-DIONES
    BELLASIO, E
    ARRIGONI.E
    FARMACO-EDIZIONE SCIENTIFICA, 1972, 27 (08): : 627 - &
  • [24] STUDIES ON ANTI-INFLAMMATORY AGENTS .39. EFFECTS OF 2-(5-H-[1]BENZOPYRANO[2,3-B]PYRIDIN-7-YL)PROPIONIC ACID (Y-8004) ON LEUKOCYTE EMIGRATION AND ENZYME-RELEASE FROM EMIGRATED LEUKOCYTES INVIVO
    GOTO, K
    HISADOME, M
    IMAMURA, H
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1976, 96 (08): : 1013 - 1021
  • [25] SYNTHESIS OF THE METABOLITES AND DEGRADATION PRODUCTS OF 2-AMINO-7-ISOPROPYL-5-OXO-5H-[1]BENZOPYRANO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID (AMOXANOX)
    UKAWA, K
    ISHIGURO, T
    KURIKI, H
    NOHARA, A
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1985, 33 (10) : 4432 - 4437
  • [26] PHARMACOLOGICAL STUDIES OF 2-(5H-[1] BENZOPYRANO (2, 3-B) PYRIDIN-7-YL) PROPIONIC-ACID (Y-8004) .3. INTERACTIONS OF Y-8004 WITH ANTI-INFLAMMATORY AGENTS
    MARUYAMA, Y
    IMAYOSHI, T
    GOTO, K
    KADOBE, Y
    FOLIA PHARMACOLOGICA JAPONICA, 1977, 73 (01) : 113 - 122
  • [27] SYNTHESES OF DERIVATIVES OF 1,2,3,4-TETRAHYDRO-5H-[1]BENZOPYRANO[2,3-B]PYRIDIN-5-ONE
    NANTKANAMIRSKI, P
    PIECHACZEK, J
    WROTEK, J
    ACTA POLONIAE PHARMACEUTICA, 1976, 33 (06): : 669 - 672
  • [28] SOME CHEMICAL AND PHARMACOLOGICAL PROPERTIES OF 2-METHYL-5H(1)BENZOPYRANO[2,3-B] PYRID-5-ONE
    NANTKANAMIRSKI, P
    PIECHACZEK, J
    POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY, 1976, 28 (01): : 89 - 94
  • [29] SYNTHESIS, PHARMACOLOGICAL ACTIVITY AND BIOPHARMACEUTICAL CHARACTERISTICS OF ALPHA,2-DIMETHYL-5H-[1]BENZOPYRANO[2,3-B]PYRIDINE-7-ACETATES
    KAWASAKI, K
    YAMADA, I
    OE, T
    TSURUDA, M
    TERASAWA, M
    IMAYOSHI, T
    YASUNAGA, Y
    GOTO, K
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1989, 109 (11): : 827 - 834
  • [30] Synthesis of [1]benzopyrano[2,3-b]pyrrol-4(1H)-ones
    Alberola, A
    Alvaro, R
    Ortega, AG
    Sanudo, C
    TETRAHEDRON, 1997, 53 (47) : 16185 - 16194
12345