STRUCTURAL OPTIMIZATION OF ALKYL-SUBSTITUTED 2-(7-5H-[1]BENZOPYRANO[2,3-B]PYRIDYL)PROPIONIC ACID AS ANTIINFLAMMATORY AGENTS

被引：1
|
作者：
NAKA, Y
YAMADA, I
OCHI, H
MATSUURA, M
NAGAMATSU, Y
OE, T
机构：
[1] Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd. 955 Koiwai, Chikujo-gun, Fukuoka, 871, Yoshitomi-cho
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 09期
关键词：
D O I：
10.1016/0960-894X(95)00141-F
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several alkyl-analogues of pranoprofen were synthesized and their cyclooxygenase inhibitory activities were evaluated in a screening test. The chosen compounds were analyzed on the relationships between structure, lipophilicity (log P) and cell binding affinity. 2-Methyl analogue (4b) was confirmed to be an optimal compound in this series.
引用
收藏
页码：959 / 962
页数：4
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