POSTSPLENECTOMIC HYPERTHROMBOCYTIC SYNDROME IN PATIENTS WITH CHRONIC MYELOID-LEUKEMIA

One of the clinical features of chronic myeloid leukemia (CML) after splenectomy lies in the development of an unusual hyperthrombocytic syndrome. In the course of a long-term observation, 12 out of 14 patients subjected to splenectomy demonstrated maximum thrombocytosis ranging from 1.008.10(9) to 3.053.10(9)/1. Hemorrhagic manifestations occurred in 6 patients, no thromboses were recorded. Postsplenectomic hyperthrombocytosis is to a certain measure resistant to cytostatic therapy. Dissociation may occur - good readings of the leukogram with a high hyperthrombocytosis. According to the authors' and reported data, the postsplenectomic hyperthrombocytic syndrome in ALL patients is fraught with the danger of the occurrence of hemorrhagic manifestations and, to a less degree, of thromboses.