The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism

被引：30

作者：

Gordon, Donna M. ^{[1
]}

Santos, Janine Hertzog ^{[2
]}

机构：

[1] Mississippi State Univ, Dept Biol Sci, Mississippi State, MS 39762 USA

[2] UMDNJ, New Jersey Med Sch, Dept Pharmacol & Physiol, 185 South Orange Ave,Med Sci Bldg,H653, Newark, NJ 07103 USA

来源：

JOURNAL OF NUCLEIC ACIDS | 2010年 / 2010卷

关键词：

D O I：

10.4061/2010/390791

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a role in mitochondrial DNA metabolism. This paper discusses the available data on mitochondrial telomerase with particular emphasis on its effects upon the organellar DNA.

引用

页数：7

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