SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW PYRIDAZINE DERIVATIVES

被引：6
|
作者：
ABDELGHANI, E
ASSY, MG
MOUSTAFA, HY
机构：
[1] Chemistry Department, Faculty of Science, Zagazig University, Zagazig
来源：
MONATSHEFTE FUR CHEMIE | 1995年 / 126卷 / 11期
关键词：
PYRIDAZINONE; PYRIDAZINETHIONE; CHLOROPYRIDIAZINE;
D O I：
10.1007/BF00824306
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Condensation of beta-aroyl-alpha-[1,3-diphenyl-5(4H)-oxo-pyrazol-4-yl] propionic acid with hydrazine hydrate affords 4,5-dihydro-3(2H)-pyridazinone (2). Reaction of 2 with POCl3 and P2S5 gives a dichloro derivative (7) and a dithione (4). The behavior of the dichloro and dithione derivatives toward various reagents was studied. The in vitro antibacterial screening reveals moderate activities against certain bacteria.
引用
收藏
页码：1265 / 1270
页数：6
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