AN EFFICIENT ROUTE TO A KEY A-RING SYNTHON FOR 1-ALPHA,25-DIHYDROXYVITAMIN D-3 AND ITS ANALOGS

被引：51
|
作者：
HATAKEYAMA, S [1 ]
IRIE, H [1 ]
SHINTANI, T [1 ]
NOGUCHI, Y [1 ]
YAMADA, H [1 ]
NISHIZAWA, M [1 ]
机构：
[1] TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN
来源：
TETRAHEDRON | 1994年 / 50卷 / 47期
关键词：
D O I：
10.1016/S0040-4020(01)89344-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and highly stereoselective route to the Roche's A-ring synthon of 1 alpha,25-dihydroxyvitamin D-3 from R-(-)-epichlorohydrin has been developed utilizing double propargylation of R-(-)-epichlorohydrin and palladium(0) catalyzed intramolecular Heck type of reaction of the omega-vinyl(Z)-iodoalkene as key steps.
引用
收藏
页码：13369 / 13376
页数：8
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