CIRCULATING SERUM INTERFERON AND ITS EFFECT ON THE ACTIVITY OF HUMAN NATURAL-KILLER-CELLS

被引：0
|
作者：
CHEKNEV, SB
ASHMANOVA, YG
PRITSKER, AD
LATYSHEVA, OL
机构：
[1] RUSSIAN ACAD MED SCI,NF GAMALEYA EPIDEMIOL & MICROBIOL INST,DEPT INTERFERONS,IMMUNOCHEM LAB,MOSCOW,RUSSIA
[2] NI PIROGOV MUNICIPAL HOSP 1,DEPT NEUROL,MOSCOW,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 12期
关键词：
CIRCULATING INTERFERON; NATURAL KILLER ACTIVITY;
D O I：
10.1007/BF02445738
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The interferon content in the plasma of 6 healthy donors and 10 patients with multiple sclerosis and the effect of an 1-h treatment of mononuclear cells with autologous plasma on their natural killer activity are studied in vitro using H-3-uridine-labeled (3 mu Ci/ml) human erythromyeloleukosis cells K-562. The serum interferon content in healthy donors is 2.3+/-0.82 IU/ml, whereas that in patients is higher: 5.2+/-0.8 IU/ml. Autologous plasma does not affect the activity of natural killer cells in vitro, whereas it increases the cytotoxicity of mononuclear cells obtained from patients with multiple sclerosis by 35-64%.
引用
收藏
页码：1311 / 1314
页数：4
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