SYNTHESIS OF PHENYL HYDRAZINE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

被引：13
|
作者：
Venkataramana, H. S. C. [1 ]
Singh, A. [2 ]
Tiwari, A. [1 ]
Tiwari, V [1 ]
机构：
[1] MS Ramaiah Coll Pharm, Dept Pharmaceut Chem, Bangalore, Karnataka, India
[2] Devsthali Vidyapeeth Coll Pharm, Rudrapur, Uttrakhand, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2010年 / 1卷 / 01期
关键词：
2-chloromethyl benzimidazole; phenyl hydrazine; antimicrobial activity;
D O I：
10.13040/IJPSR.0975-8232.1(1).34-38
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding NN' disubstituted hydrazines. The synthesized compounds were subjected to microbiological screening and Invitro anti-inflammatory activity.
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页数：5
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