SYNTHESIS OF PHENYL HYDRAZINE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

被引：13
|
作者：
Venkataramana, H. S. C. [1 ]
Singh, A. [2 ]
Tiwari, A. [1 ]
Tiwari, V [1 ]
机构：
[1] MS Ramaiah Coll Pharm, Dept Pharmaceut Chem, Bangalore, Karnataka, India
[2] Devsthali Vidyapeeth Coll Pharm, Rudrapur, Uttrakhand, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2010年 / 1卷 / 01期
关键词：
2-chloromethyl benzimidazole; phenyl hydrazine; antimicrobial activity;
D O I：
10.13040/IJPSR.0975-8232.1(1).34-38
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding NN' disubstituted hydrazines. The synthesized compounds were subjected to microbiological screening and Invitro anti-inflammatory activity.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1-SUBSTITUTED BENZIMIDAZOLE AND BENZTRIAZOLE DERIVATIVES
    VARTANYAN, RS
    MARTIROSYAN, VO
    VLASENKO, EV
    OVASAPYAN, AA
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1982, 16 (08): : 947 - 951
  • [2] Design, synthesis and biological activity evaluation of novel methyl substituted benzimidazole derivatives
    Zhang, Tianrong
    Liu, Qianqian
    Ren, Yujie
    TETRAHEDRON, 2020, 76 (13)
  • [3] Synthesis and Biological Activity of Pyrazolidine-3,5-Dione Substituted Benzimidazole Derivatives
    Tiwari, Abhishek
    Tiwari, Varsha
    Venkataramana, C. H. S.
    Madhavan, V.
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (03) : 1179 - 1182
  • [4] Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole
    Vasic, Vesna P.
    Penjisevic, Jelena Z.
    Novakovic, Irena T.
    Sukalovic, Vladimir V.
    Andric, Deana B.
    Kostic-Rajacic, Sladana V.
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2014, 79 (03) : 277 - 282
  • [5] Synthesis and biological evaluation of 2-substituted benzimidazole derivatives
    Mariappan, Gurusamy
    Hazarika, Rajib
    Alam, Faruk
    Karki, Rashmi
    Patangia, Uddhav
    Nath, Shyamalendu
    ARABIAN JOURNAL OF CHEMISTRY, 2015, 8 (05) : 715 - 719
  • [6] MICROWAVE ASSISTED IMPROVED METHOD FOR THE SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDE DERIVATIVES
    Bendre, Ratnamala S.
    Hadole, Chakradhar D.
    Makasare, Sandeep P.
    HETEROCYCLIC LETTERS, 2015, 5 (02): : 269 - 277
  • [7] Synthesis and antimicrobial activity of 1-dialkylaminomethyl-2-(p-substituted phenyl)-5-substituted benzimidazole derivatives
    Ersan, S
    Nacak, S
    Acar, N
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 1997, 47 (04): : 410 - 412
  • [8] Synthesis and antimicrobial activity of substituted benzimidazole, benzothiazole and imidazole derivatives
    Kucukbay, H
    Cetinkaya, E
    Durmaz, R
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1995, 45-2 (12): : 1331 - 1334
  • [9] Synthesis and biological evaluation of some substituted benzimidazole derivatives as antihypertensive activities
    Sharma, Mukesh Chandra
    Kohli, Dharm Veer
    ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL, 2023, 12 (01): : 638 - 647
  • [10] Synthesis and herbicidal activity of substituted phenyl pyrazole derivatives
    Zhou, YH
    Miao, WR
    Cheng, LB
    Wang, DX
    Bai, ZS
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2003, 24 (07): : 1225 - 1230
12345