N-(1-METHYL-5-INDOLYL)-N'-(3-METHYL-5-ISOTHIAZOLYL)UREA - A NOVEL, HIGH-AFFINITY 5-HT2B RECEPTOR ANTAGONIST

被引:68
|
作者
FORBES, IT
JONES, GE
MURPHY, OE
HOLLAND, V
BAXTER, GS
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT NEUROL,HARLOW CM19 5AW,ESSEX,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT PSYCHIAT,HARLOW CM19 5AW,ESSEX,ENGLAND
关键词
D O I
10.1021/jm00006a001
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:855 / 857
页数:3
相关论文
共 50 条
  • [21] 3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands
    Porter, Matthew R.
    Xiao, Haiyan
    Wang, Jing
    Smith, Sylvia B.
    Topczewski, Joseph J.
    ACS MEDICINAL CHEMISTRY LETTERS, 2019, 10 (10): : 1436 - 1442
  • [22] N-[ω-[4-(2-methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as high-affinity fluorescent 5-HT1A receptor ligands
    Lacivita, Enza
    Leopoldo, Marcello
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (05) : 1492 - 1495
  • [23] 2-chloro N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate is a selective high affinity P2Y1 receptor antagonist
    Boyer, JL
    Adams, M
    Ravi, RG
    Jacobson, KA
    Harden, TK
    BRITISH JOURNAL OF PHARMACOLOGY, 2002, 135 (08) : 2004 - 2010
  • [24] PHARMACOLOGICAL PROFILE OF (-)HT-90B, A NOVEL 5-HT1A RECEPTOR AGONIST 5-HT2 RECEPTOR ANTAGONIST
    UCHIDA, H
    INAGAWA, K
    TAMEDA, C
    MIYAUCHI, T
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1995, 19 (07): : 1201 - 1216
  • [25] N-[(1-LONG ALKYL-2-PYRROLIDINYL)METHYL]BENZAMIDES WITH POTENT SEROTONIN 5-HT1A RECEPTOR AFFINITIES
    IKEBE, T
    MURAKAMI, S
    TAKEHARA, S
    SAKAMORI, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1991, 39 (12) : 3370 - 3372
  • [26] (1R, 3S)-(-)-Trans-PAT: A novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity
    Booth, Raymond G.
    Fang, Lijuan
    Huang, Yingsu
    Wilczynski, Andrzej
    Sivendran, Sashikala
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 615 (1-3) : 1 - 9
  • [27] Antinociceptive pharmacology of N-(4-chlorobenzyl)-N′-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor
    Tang, Lei
    Chen, Yan
    Chen, Zili
    Blumberg, Peter M.
    Kozikowski, Alan P.
    Wang, Zaijie Jim
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007, 321 (02): : 791 - 798
  • [28] A Novel Highly Selective 5-Hydroxytryptamine 2B (5-HT2B) Receptor Antagonist Ameliorating Fibrosis in Preclinical Models of Systemic Sclerosis
    Wenglen, Christina
    Pettersson, Lars
    Arozenius, Helena
    Ekstrom, Gunilla
    ARTHRITIS & RHEUMATOLOGY, 2016, 68
  • [29] A NOVEL HIGHLY SELECTIVE 5-HYDROXYTRYPTAMINE 2B (5-HT2B) RECEPTOR ANTAGONIST AMELIORATING FIBROSIS IN PRECLINICAL MODELS OF SYSTEMIC SCLEROSIS
    Wenglen, C.
    Pettersson, L.
    Arozenius, H.
    Ekstrom, G.
    ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : 891 - 891
  • [30] Synthesis of N-[5-(guanidinopentyl)-N-[3-[(3-methyl-1-oxo-2 butenyl) amino] propyldodecanamide
    Abdalla, Walwil M.
    RESEARCH JOURNAL OF CHEMISTRY AND ENVIRONMENT, 2008, 12 (04): : 70 - 75