ENDOTHELINS AND SARAFOTOXINS - PHYSIOLOGICAL REGULATION, RECEPTOR SUBTYPES AND TRANSMEMBRANE SIGNALING

被引：60
|
作者：
SOKOLOVSKY, M
机构：
[1] M. Sokolovsky is at the Laboratory of Neurobiochemistry, Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 07期
关键词：
D O I：
10.1016/0968-0004(91)90100-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The endothelins and sarafotoxins are two structurally related families of potent vasoactive peptides. Although the exact physiological function of these peptides is not known, the endothelins are probably involved in pathophysiological conditions such as hypertension and heart failure. This article will review the biochemistry of these peptides and their receptors, with special reference to proteolytic regulation, receptor subtypes and the G protein-linked phosphoinositide signal transduction pathway.
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收藏
页码：261 / 264
页数：4
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