THE DYNEMICIN DNA INTERCALATION COMPLEX - A MODEL BASED ON DNA AFFINITY CLEAVAGE AND MOLECULAR-DYNAMICS SIMULATION

被引：75
|
作者：
LANGLEY, DR [1 ]
DOYLE, TW [1 ]
BEVERIDGE, DL [1 ]
机构：
[1] WESLEYAN UNIV,DEPT CHEM,HALL ATWATER LABS,MIDDLETOWN,CT 06457
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1991年 / 113卷 / 12期
关键词：
D O I：
10.1021/ja00012a004
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A model for the dynemicin-DNA complex has been constructed by using energy minimization (EM) and molecular dynamics (MD) techniques. The model is consistent with the available experimental data. This has allowed us to gain insights into (1) how dynemicin A is activated into a DNA cleaver, (2) its mode of binding to DNA, (3) the absolute stereochemistry of dynemicin A, and (4) its DNA cleavage patterns and specificity.
引用
收藏
页码：4395 / 4403
页数：9
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