A CONVENIENT SYNTHESIS OF THE TOXICOPHORIC FURO[2,3-B]BENZOFURAN FRAGMENT PRESENT IN AFLATOXIN M1

被引：0

作者：

BUJONS, J ^{[1
]}

ROURA, L ^{[1
]}

MESSEGUER, A ^{[1
]}

机构：

[1] CID,CSIC,DEPT BIOL ORGAN CHEM,J GIRONA 18,E-08034 BARCELONA,SPAIN

来源：

SYNLETT | 1994年 / 06期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot procedure involving four reaction steps (enolate formation, epoxidation, epoxide opening and deprotection), constitutes the key process for obtaining the hydroxyfuro[2,3-b]benzofuran moiety present in aflatoxin M1. The above sequential reactions led to the generation of the benzopyran aldehyde 8. As expected, this aldehyde underwent equilibration in solution giving rise to the epimeric mixture of dihydroxyfuro[2,3-b]benzofurans 9 as major components. This epimeric mixture was easily converted into the toxicophoric aflatoxin M1 fragment 10.

引用

页码：437 / 438

页数：2

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