DETECTION OF ANTIBODY TO HEPATITIS-C E2/NS1 PROTEIN IN PATIENTS WITH TYPE-C HEPATITIS

被引：5
|
作者：
YOKOSUKA, O [1 ]
ITO, Y [1 ]
IMAZEKI, F [1 ]
OHTO, M [1 ]
OMATA, M [1 ]
机构：
[1] CHIBA UNIV,SCH MED,DEPT MED 1,CHUO KU,CHIBA 260,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 01期
关键词：
D O I：
10.1016/0006-291X(92)91595-H
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Putative E2/NS1 sequence of hepatitis C virus was expressed in E. coli as a fusion protein with maltose binding protein. Approximately 80 kDa protein was obtained containing 38 kDa E2/NS1 protein. The antibody to this protein was detectable in the same serum from which the sequence was amplified. It was also detectable in none of 7 acute hepatitis, in 2 of 12 chronic persistent hepatitis, in 3 of 25 chronic active hepatitis, and in 2 of 4 cirrhosis. It was detectable in none of 10 normal subjects. In 3 cases who were positive for the antibody before the interferon treatment, it became undetectable after the treatment. Thus,it seems that the antibody is not a neutralizing antibody and is related to active viral replication. © 1992.
引用
收藏
页码：565 / 571
页数：7
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