NEUROTROPIC EFFECT OF MYELOPID ON THE MOTOR-ACTIVITY OF RATS - STEREOTYPICAL MOVEMENTS, LOCOMOTION, AND GROOMING

被引：0
|
作者：
LEPEKHINA, LM
BIBIKOVA, LA
机构：
[1] SM KIROV MIL MED ACAD,ST PETERSBURG,RUSSIA
[2] IM SECHENOV INST EVOLUT PHYSIOL & BIOCHEM,MOSCOW,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 10期
关键词：
NEUROTROPIC EFFECT; MOTOR ACTIVITY; MYELOPID; ATROPINE; HEXONIUM;
D O I：
10.1007/BF02446473
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
It is shown that myelopid, a new immunoregulating preparation isolated from bone marrow, modulates motor activity in rats and, consequently, possesses neurotropic activity. Presumably, the activating effect of myelopid on stereotypical movements is realized via stimulation of presynaptic receptors and subsequent activation of dopamine of the mesolimbic system, since this effect is abolished by the M-cholinoreceptor blocker atropine. The inhibitory effect on scratching may be a result of the inhibitory influence of myelopid on preganglionic sympathetic neurons of the spinal cord, since it was abolished by the blocker of ganglionic H-cholinoreceptors hexonium.
引用
收藏
页码：1114 / 1116
页数：3
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