NEUROTROPIC EFFECT OF MYELOPID ON THE MOTOR-ACTIVITY OF RATS - STEREOTYPICAL MOVEMENTS, LOCOMOTION, AND GROOMING

It is shown that myelopid, a new immunoregulating preparation isolated from bone marrow, modulates motor activity in rats and, consequently, possesses neurotropic activity. Presumably, the activating effect of myelopid on stereotypical movements is realized via stimulation of presynaptic receptors and subsequent activation of dopamine of the mesolimbic system, since this effect is abolished by the M-cholinoreceptor blocker atropine. The inhibitory effect on scratching may be a result of the inhibitory influence of myelopid on preganglionic sympathetic neurons of the spinal cord, since it was abolished by the blocker of ganglionic H-cholinoreceptors hexonium.