Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities

被引：0

作者：

Bazgir, Ayoob ^{[1
]}

Azimi, Seyyedeh Cobra ^{[2
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

[2] Islamic Azad Univ, Young Researchers Club, Rasht Branch, Rasht, Iran

来源：

IRANIAN JOURNAL OF CATALYSIS | 2013年 / 3卷 / 01期

关键词：

Ionic liquid; Pyrimido[4,5-dJpyrimidine-2,4-dione; 6-Amino-uracil; Antibacterial activities;

D O I：

暂无

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity, simple workup and reusability of ionic liquid. These products were evaluated in vitro for their antibacterial activities.

引用

页码：21 / 26

页数：6

共 50 条

[21] Regiospecific one-pot synthesis of pyrimido[4,5-d]pyrimidine derivatives in the solid state under microwave irradiations
Prajapati, D
Gohain, M
Thakur, AJ
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (13) : 3537 - 3540
[22] An efficient one-pot three-component synthesis of pyrimido[4,5-d]pyrimidine derivatives in aqueous medium
Sreedhar Badvel
Raveendra Reddy Gopireddy
Thaslim Basha Shaik
Sudhamani Hasti
Veera Reddy Tummaluru
Naga Raju Chamarthi
Chemistry of Heterocyclic Compounds, 2015, 51 : 749 - 753
[23] Graphene Oxide Catalyzed One-pot Synthesis of Pyrimido[4,5-b]quinolinone-2,4-diones and their Biological Evaluation
Singha, Rabindranath
Basak, Puja
Bhattacharya, Malay
Ghosh, Pranab
CHEMISTRYSELECT, 2020, 5 (21): : 6514 - 6525
[24] PTSA-Catalyzed Cyclization of 6-Aminouracils with Diimines: Efficient Synthesis of Functionalized Tetrahydropyrimido[4,5-d]pyrimidine-2,4-diones
Khodabakhshi, Mohammad R.
Kiamehr, Mostafa
Moghaddam, Firouz M.
Villinger, Alexander
Langer, Peter
CHEMISTRYSELECT, 2018, 3 (41): : 11671 - 11676
[25] Ionic liquid promoted one-pot synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones
Shaabani, Ahmad
Soleimani, Ebrahim
Darvishi, Maria
MONATSHEFTE FUR CHEMIE, 2007, 138 (01): : 43 - 46
[26] Ionic Liquid Promoted One-Pot Synthesis of Furo[2,3-d]pyrimidine-2,4(1H,3H)-diones
Ahmad Shaabani
Ebrahim Soleimani
Maria Darvishi
Monatshefte für Chemie - Chemical Monthly, 2007, 138 : 43 - 46
[27] STUDY OF THIAZOLO[4,5-D]PYRIMIDINES - THE SYNTHESIS OF THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONES AND NOVEL RING-OPENING TO 2,4-THIAZOLIDINEDIONE
NAGAHARA, K
SEKINE, M
TAKADA, A
COTTAM, HB
ROBINS, RK
HETEROCYCLES, 1993, 36 (05) : 923 - 927
[28] One pot synthesis of pyrimido[4,5-D]pyrimidine ring system:: New class of folate analogs.
Zand, AR
Thoma, J
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U164 - U165
[29] Antibacterial, antifungal and antiviral activities of pyrimido [4,5-d]pyrimidine derivatives through computational approaches
Alam, Mahbub
Kobir, Md Eleas
Kumer, Ajoy
Chakma, Unesco
Akter, Parul
Bhuiyan, Md Mosharef Hossain
ORGANIC COMMUNICATIONS, 2022, 15 (03) : 239 - 260
[30] SYNTHESIS AND ANTIVIRAL STUDY OF CYCLOPENTANO[D]PYRIMIDINE-2,4-DIONES AND OCTAHYDROQUINAZOLINE-2,4-DIONES ACYCLIC NUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS
RENAULT, J
LADUREE, D
ROBBA, M
NUCLEOSIDES & NUCLEOTIDES, 1994, 13 (04): : 891 - 901

← 1 2 3 4 5 →