BRAIN PH AND LACTIC-ACIDOSIS - QUANTITATIVE-ANALYSIS OF TAURINE EFFECT

被引：9
|
作者：
NAKADA, T [1 ]
HIDA, K [1 ]
KWEE, IL [1 ]
机构：
[1] UNIV CALIF DAVIS,DEPT NEUROL,DAVIS,CA 95616
来源：
NEUROSCIENCE RESEARCH | 1992年 / 15卷 / 1-2期
关键词：
BRAIN PH; LACTIC ACIDOSIS; TAURINE;
D O I：
10.1016/0168-0102(92)90024-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A quantitative analysis of taurine effect (facilitation of acid handling capacity of brain in response to anoxia/hypoxia by high levels of cytosolic taurine) was performed utilizing multinuclear (H-1, P-31) in vivo nuclear magnetic resonance (NMR) spectroscopy and in vitro titration analysis. Taurine effects observed in vivo showed excellent quantitative agreement with the predicted values estimated based on brain taurine levels. The study confirmed that high levels of cytosolic taurine indeed facilitate acid buffering capacity of brain and this taurine effect can be readily explained by the physical, and need not involve metabolic, properties of taurine. Taurine appears to be a key component of the brain cytosol system in the fetus.
引用
收藏
页码：115 / 123
页数：9
相关论文
共 50 条
  • [31] EFFECT OF LACTIC-ACIDOSIS ON CANINE HEMODYNAMICS AND LEFT-VENTRICULAR FUNCTION
    TEPLINSKY, K
    OTOOLE, M
    OLMAN, M
    WALLEY, KR
    WOOD, LDH
    AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (04): : H1193 - H1199
  • [32] BICARBONATE ADMINISTRATION DOES NOT CAUSE A PARADOXICAL BRAIN INTRACELLULAR ACIDOSIS DURING RECOVERY FROM HYPOXIC LACTIC-ACIDOSIS
    SESSLER, DI
    MILLS, P
    GREGORY, GA
    LITT, L
    JAMES, TL
    ANESTHESIOLOGY, 1986, 65 (3A) : A442 - A442
  • [33] BRAIN LACTIC-ACIDOSIS AND ISCHEMIC CELL-DAMAGE - QUANTITATIVE ULTRASTRUCTURAL-CHANGES IN CAPILLARIES OF RAT CEREBRAL-CORTEX
    PALJARVI, L
    REHNCRONA, S
    SODERFELDT, B
    OLSSON, Y
    KALIMO, H
    ACTA NEUROPATHOLOGICA, 1983, 60 (3-4) : 232 - 240
  • [34] BRAIN LACTIC-ACIDOSIS AND ISCHEMIC CELL-DAMAGE .1. BIOCHEMISTRY AND NEUROPHYSIOLOGY
    REHNCRONA, S
    ROSEN, I
    SIESJO, BK
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1981, 1 (03): : 297 - 311
  • [35] EFFECT OF THIOPEPTIN AND SODIUM-BICARBONATE ON THE PREVENTION OF LACTIC-ACIDOSIS INDUCED IN SHEEP
    KEZAR, WW
    CHURCH, DC
    JOURNAL OF ANIMAL SCIENCE, 1979, 49 (05) : 1396 - 1402
  • [36] QUANTITATIVE-ANALYSIS OF BRAIN SCANS
    YEH, EL
    MEADE, RC
    JOURNAL OF NUCLEAR MEDICINE, 1973, 14 (03) : 176 - 178
  • [37] EFFECT OF DIFFERENT DEGREES OF BRAIN ISCHEMIA AND TISSUE LACTIC-ACIDOSIS ON THE SHORT-TERM RECOVERY OF NEUROPHYSIOLOGIC AND METABOLIC VARIABLES
    REHNCRONA, S
    ROSEN, I
    SMITH, ML
    EXPERIMENTAL NEUROLOGY, 1985, 87 (03) : 458 - 473
  • [38] CSF BRAIN CREATINE-KINASE LEVELS AND LACTIC-ACIDOSIS IN SEVERE HEAD-INJURY
    RABOW, L
    DESALLES, AAF
    BECKER, DP
    YANG, M
    KONTOS, HA
    WARD, JD
    MOULTON, RJ
    CLIFTON, G
    GRUEMER, HD
    MUIZELAAR, JP
    MARMAROU, A
    JOURNAL OF NEUROSURGERY, 1986, 65 (05) : 625 - 629
  • [39] INDUCTION OF LACTIC-ACIDOSIS IN CATTLE WITH SUCROSE - RELATIONSHIP BETWEEN DOSE, RUMEN FLUID PH AND ANIMAL SIZE
    ORTOLANI, EL
    VETERINARY AND HUMAN TOXICOLOGY, 1995, 37 (05) : 462 - 464
  • [40] INFLUENCE OF INVITRO LACTIC-ACIDOSIS AND HYPERCAPNIA ON RESPIRATORY ACTIVITY OF ISOLATED RAT-BRAIN MITOCHONDRIA
    HILLERED, L
    ERNSTER, L
    SIESJO, BK
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1984, 4 (03): : 430 - 437
12345