Electro-oxidation and Determination of Gabapentin at Copper Sulfide Nanostructures Modified Carbon Paste Electrode

For the first time, a carbon paste electrode modified with copper sulfide nanostructures for determination of gabapentin (GP) was described. In CV studies, no oxidation response of gabapentin can be seen at the unmodified electrode, but at the copper sulfide nanostructures modified carbon paste electrode (CSN-MCPE), a large anodic peak appears, indicating that the anodic oxidation of gabapentin could be catalyzed at CSN-MCPE. This proves that the copper sulfide nanostructures bear the main role in electrocatalytic oxidation of gabapentin. It has been shown that using the CSN-MCPE, gabapentin can be determined by DPV and amperometry with limit of detections 0.5 and 0.73 mu mol L-1, respectively. The electrode response towards gabapentin was quite reproducible and a long-term stability of the electrode (more than 45 day) was observed. Furthermore, the proposed modified electrode was successfully applied to the determination of gabapentin in real samples. High sensitivity, excellent selectivity and ease of preparation are acknowledges of this electrode.