HIPPOCAMPAL NEURONAL LOSS AND REGIONAL HYPOMETABOLISM IN TEMPORAL-LOBE EPILEPSY

被引：104
|
作者：
HENRY, TR
BABB, TL
ENGEL, J
MAZZIOTTA, JC
PHELPS, ME
CRANDALL, PH
机构：
[1] UNIV CALIF LOS ANGELES,DEPT ANAT & CELL BIOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
[3] UNIV CALIF LOS ANGELES,DEPT NEUROSURG,LOS ANGELES,CA 90024
[4] UNIV CALIF LOS ANGELES,DEPT PHARMACOL,LOS ANGELES,CA 90024
[5] UNIV CALIF LOS ANGELES,DEPT RADIOL SCI,LOS ANGELES,CA 90024
来源：
ANNALS OF NEUROLOGY | 1994年 / 36卷 / 06期
关键词：
D O I：
10.1002/ana.410360620
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative [F-18]fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.
引用
收藏
页码：925 / 927
页数：3
相关论文
共 50 条
  • [41] INTRACTABLE TEMPORAL-LOBE EPILEPSY WITH CALCIFIED MASS IN THE TEMPORAL-LOBE
    YAMAMOTO, K
    TANAKA, T
    FUJITA, T
    FUKUDA, H
    YONEMASU, Y
    JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY, 1993, 47 (02): : 262 - 263
  • [42] THE CLINICAL-PATHOGENIC MECHANISMS OF HIPPOCAMPAL NEURON LOSS AND SURGICAL OUTCOMES IN TEMPORAL-LOBE EPILEPSY
    MATHERN, GW
    BABB, TL
    VICKREY, BG
    MELENDEZ, M
    PRETORIUS, JK
    BRAIN, 1995, 118 : 105 - 118
  • [43] Hippocampal neuronal density and temporal lobe epilepsy.
    Kim, JH
    deLanerolle, N
    Spencer, S
    Sass, K
    Bronen, R
    Spencer, D
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (05): : 11 - 11
  • [44] A REPRODUCIBLE SEMIQUANTITATIVE METHOD FOR DISCRIMINATING TEMPORAL-LOBE HYPOMETABOLISM IN PARTIAL EPILEPSY WITH FDG PET
    GRAFTON, ST
    GUAN, SI
    DEGIORGIO, C
    RABINOWICZ, A
    CONTI, PS
    NEUROLOGY, 1994, 44 (04) : A384 - A384
  • [45] The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy
    Wang, Jie
    Chen, Yanjun
    Wang, Qiong
    van Luijtelaar, Gilles
    Sun, Meizhen
    BRAIN RESEARCH, 2019, 1712 : 1 - 6
  • [46] SPATIOTEMPORAL DYNAMICS OF THE PRIMARY EPILEPTOGENIC AREA IN TEMPORAL-LOBE EPILEPSY CHARACTERIZED BY NEURONAL COMPLEXITY LOSS
    LEHNERTZ, K
    ELGER, CE
    ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1995, 95 (02): : 108 - 117
  • [47] PREFERENTIAL NEURONAL LOSS IN LAYER-III OF THE ENTORHINAL CORTEX IN PATIENTS WITH TEMPORAL-LOBE EPILEPSY
    DU, F
    WHETSELL, WO
    ABOUKHALIL, B
    BLUMENKOPF, B
    LOTHMAN, EW
    SCHWARCZ, R
    EPILEPSY RESEARCH, 1993, 16 (03) : 223 - 233
  • [48] NEURONAL COMPLEXITY LOSS OF THE CONTRALATERAL HIPPOCAMPUS IN TEMPORAL-LOBE EPILEPSY - A POSSIBLE INDICATOR FOR SECONDARY EPILEPTOGENESIS
    LEHNERTZ, K
    ELGER, CE
    EPILEPSIA, 1995, 36 : 170 - 170
  • [49] CORRELATION OF PET FDG HYPOMETABOLISM AND INDETERMINATE MRI VOLUMETRICS IN PATIENTS WITH TEMPORAL-LOBE EPILEPSY
    RAJA, S
    IMAD, N
    COMAIR, YG
    HAROLD, MH
    KOTAGAL, P
    LUDERS, HO
    KHANDEKAR, S
    SAHA, GB
    MACINTYRE, WJ
    GO, RT
    EPILEPSIA, 1995, 36 : 663 - 663
  • [50] SYMPOSIUM - TEMPORAL-LOBE EPILEPSY
    SATO, M
    MIYASAKA, M
    JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY, 1994, 48 (02): : 203 - 204
12345