CHROMOSOME ASSIGNMENTS OF THE HUMAN TNF P55 AND P75 RECEPTOR GENES

被引：1

作者：

BROWNELL, E

RANGES, GE

SARR, T

FIORENTINO, L

GODFREY, M

PEKAR, S

HART, J

KAMARCK, M

RAE, PMM

RUDDLE, FH

BAYNEY, R

机构：

[1] MILES RES CTR,INST ARTHRITIS & AUTOIMMUN,W HAVEN,CT 06516

[2] YALE UNIV,DEPT BIOL,NEW HAVEN,CT 06520

来源：

JOURNAL OF EXPERIMENTAL ZOOLOGY | 1992年 / 262卷 / 03期

关键词：

D O I：

10.1002/jez.1402620314

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

At least two different receptor molecules have been described that are capable of binding tumor necrosis factor alpha, a cytokine that plays an important role in inflammation and antitumor activity. Comparative analyses at the nucleotide sequence level suggest that these receptors are members of a newly defined protein family that also includes human and rat nerve growth factor receptors. In this study, we determine the chromosome assignments of the human TNF alpha receptor genes, one of which may have evolved as part of a conserved Hox locus-containing chromosome segment.

引用

页码：340 / 342

页数：3

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