Prognostic markers of urinary bladder cancer recurrence and lymphatic spread

Treatment results 2005-2009) for patients with surface n = 104) and invasive n = 104) urinary bladder carcinoma were analyzed. Molecular genetic analysis of cytochrome gene P450 polymorphous locus carried out: CYP1.1 A2455G),.YP1A2 T-2464delT), Glutathione S-transferase: GSTM1 del), GSTP1 A313G); DNA reparation: XRCC1 G28152A) for patients with surface urine bladder carcinoma recurrence, which took place within a year, and for patients with surface urine bladder carcinoma without recurrence within a year. Genotypes associated with surface urine bladder carcinoma one-year recurrence were identified. Furthermore, analysis of these genes polymorphous locsus of patients with invasive urine bladder carcinoma with and without lymphogenic metastases was carried out. Genotypes associated with lyphogenic metastasis risk were identified.