ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .65. EFFICIENT ASYMMETRIC HYDROGENATION OF ALPHA-AMINO KETONE DERIVATIVES - A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF PHENYLEPHRINE, LEVAMISOLE, CARNITINE AND PROPRANOLOL

被引：0

作者：

SAKURABA, S ^{[1
]}

TAKAHASHI, H ^{[1
]}

TAKEDA, H ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, SHIZUOKA 422, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 05期

关键词：

CATALYTIC ASYMMETRIC HYDROGENATION; RHODIUM COMPLEX; CHIRAL BISPHOSPHINE; ALPHA-AMINO KETONE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The complexes of pyrrolidine bisphosphine ligands (CPMs) with rhodium (I),were found to be efficient catalysts for asymmetric hydrogenation of alpha-amino ketone hydrochloride derivatives, Utilizing this methodology, we have developed efficient asymmetric syntheses of the optically active beta-amino alcohols, phenylephrine, levamisole, carnitine and propranolol.

引用

页码：738 / 747

页数：10

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