ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .65. EFFICIENT ASYMMETRIC HYDROGENATION OF ALPHA-AMINO KETONE DERIVATIVES - A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF PHENYLEPHRINE, LEVAMISOLE, CARNITINE AND PROPRANOLOL

被引：0

作者：

SAKURABA, S ^{[1
]}

TAKAHASHI, H ^{[1
]}

TAKEDA, H ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, SHIZUOKA 422, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 05期

关键词：

CATALYTIC ASYMMETRIC HYDROGENATION; RHODIUM COMPLEX; CHIRAL BISPHOSPHINE; ALPHA-AMINO KETONE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The complexes of pyrrolidine bisphosphine ligands (CPMs) with rhodium (I),were found to be efficient catalysts for asymmetric hydrogenation of alpha-amino ketone hydrochloride derivatives, Utilizing this methodology, we have developed efficient asymmetric syntheses of the optically active beta-amino alcohols, phenylephrine, levamisole, carnitine and propranolol.

引用

页码：738 / 747

页数：10

共 50 条

[1] ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .41. HIGHLY EFFICIENT ASYMMETRIC HYDROGENATION OF AMINO KETONE DERIVATIVES LEADING TO PRACTICAL SYNTHESES OF (S)-PROPRANOLOL AND RELATED-COMPOUNDS
TAKAHASHI, H
SAKURABA, S
TAKEDA, H
ACHIWA, K
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (15) : 5876 - 5878
[2] ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .27. EFFICIENT ASYMMETRIC HYDROGENATION OF ALPHA-AMINOACETOPHENONE DERIVATIVES LEADING TO PRACTICAL SYNTHESIS OF (S)-(-)-LEVAMISOLE
TAKEDA, H
TACHINAMI, T
ABURATANI, M
TAKAHASHI, H
MORIMOTO, T
ACHIWA, K
TETRAHEDRON LETTERS, 1989, 30 (03) : 363 - 366
[3] ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .9. HIGHLY ENANTIOSELECTIVE CATALYTIC ASYMMETRIC HYDROGENATION OF ITACONIC ACID
ACHIWA, K
TETRAHEDRON LETTERS, 1978, (17) : 1475 - 1476
[4] ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .66. EFFICIENT ASYMMETRIC HYDROGENATION OF BETA-AMINO AND GAMMA-AMINO KETONE DERIVATIVES LEADING TO PRACTICAL SYNTHESIS OF FLUOXETINE AND EPROZINOL
SAKURABA, S
ACHIWA, K
CHEMICAL & PHARMACEUTICAL BULLETIN, 1995, 43 (05) : 748 - 753
[5] ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .30. HIGHLY EFFICIENT ASYMMETRIC HYDROGENATION OF ITACONIC ACID-DERIVATIVES CATALYZED BY A MODIFIED DIOP RHODIUM COMPLEX
MORIMOTO, T
CHIBA, M
ACHIWA, K
TETRAHEDRON LETTERS, 1989, 30 (06) : 735 - 738
[6] ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .37. ASYMMETRIC TOTAL SYNTHESIS OF (-)-DEOXYPODOPHYLLOTOXIN
MORIMOTO, T
CHIBA, M
ACHIWA, K
TETRAHEDRON LETTERS, 1990, 31 (02) : 261 - 264
[7] ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL-COMPLEXES .36. AN EFFICIENT SYNTHESIS OF NATURAL (+)-NEOISOSTEGANE USING ASYMMETRIC HYDROGENATION CATALYZED BY A CHIRAL BISPHOSPHINE-RHODIUM(I) COMPLEX
MORIMOTO, T
CHIBA, M
ACHIWA, K
HETEROCYCLES, 1990, 30 (01) : 363 - 366
[8] Enantioselective Synthesis of α-Acetal-β'-Amino Ketone Derivatives by Rhodium-Catalyzed Asymmetric Hydrogenation
Llopis, Quentin
Guillamot, Gerard
Phansavath, Phannarath
Ratovelomanana-Vidal, Virginie
ORGANIC LETTERS, 2017, 19 (23) : 6428 - 6431
[9] Highly Efficient Enantioselective Synthesis of Chiral Sulfones by Rh-Catalyzed Asymmetric Hydrogenation
Yan, Qiaozhi
Xiao, Guiying
Wang, Ying
Zi, Guofu
Zhang, Zhanbin
Hou, Guohua
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (04) : 1749 - 1756
[10] Highly efficient synthesis of chiral β-amino acid derivatives via asymmetric hydrogenation
Tang, WJ
Zhang, XM
ORGANIC LETTERS, 2002, 4 (23) : 4159 - 4161

← 1 2 3 4 5 →