A HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-BASED RETROVIRAL VECTOR SYSTEM UTILIZING STABLE HIV-1 PACKAGING CELL-LINES

被引：46

作者：

CARROLL, R ^{[1
]}

LIN, JT ^{[1
]}

DACQUEL, EJ ^{[1
]}

MOSCA, JD ^{[1
]}

BURKE, DS ^{[1
]}

STLOUIS, DC ^{[1
]}

机构：

[1] WALTER REED ARMY INST RES,ROCKVILLE,MD 20850

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 09期

关键词：

D O I：

10.1128/JVI.68.9.6047-6051.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4(+) cells. This HIV-1-based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4(+) cells.

引用

页码：6047 / 6051

页数：5

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