NUCLEOTIDE-SEQUENCE AND CHARACTERIZATION OF ERYTHROMYCIN RESISTANCE DETERMINANT THAT ENCODES MACROLIDE 2'-PHOSPHOTRANSFERASE-I IN ESCHERICHIA-COLI

被引：81
|
作者：
NOGUCHI, N
EMURA, A
MATSUYAMA, H
OHARA, K
SASATSU, M
KONO, M
机构：
[1] Department of Microbiology, School of Pharmacy, Tokyo Univ. of Pharmacy/Life Science, Hachioji, Tokyo 192-03
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 10期
关键词：
D O I：
10.1128/AAC.39.10.2359
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The DNA fragment (3.3 kb) containing the erythromycin resistance determinant was cloned from Escherichia coli Tf481A and sequenced. Deletion and complementation analyses indicated that the expression of high-level resistance to erythromycin requires two genes, mphA and mrx, which encode macrolide 2'-phosphotransferase I and an unidentified hydrophobic protein, respectively.
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收藏
页码：2359 / 2363
页数：5
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