INTERLEUKIN-11 INHIBITS BONE-FORMATION IN-VITRO

被引：56
|
作者：
HUGHES, FJ
HOWELLS, GL
机构：
[1] UNIV LONDON LONDON HOSP,COLL MED,DEPT ORAL MED & PERIODONTOL,TURNER ST,LONDON E1 2AD,ENGLAND
[2] UNIV LONDON LONDON HOSP,COLL MED,DEPT ORAL PATHOL,LONDON E1 2AD,ENGLAND
来源：
CALCIFIED TISSUE INTERNATIONAL | 1993年 / 53卷 / 05期
关键词：
D O I：
10.1007/BF01351844
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects of interleukin-11(IL-11) on the differentiation of osteoblast precursors was tested using a bone nodule forming assay in rat calvaria cell cultures. IL-11 caused a dose dependent inhibition of nodule formation, with 500U/ml IL-11 resulting in complete inhibition of nodule formation. IL-11 also caused a reduction in alkaline phosphatase expression in these cultures. These effects are similar to, but more potent than, the actions of IL-6 on these cells. These results indicate that IL-11 is an osteotropic cytokine and suggest that IL-11 may be an important inhibitor of bone formation in health and disease.
引用
收藏
页码：362 / 364
页数：3
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