(2R, 4S, 5S)-1-(TETRAHYDRO-4-HYDROXY-5-METHOXY-2-FURANYL)THYMINE - A POTENT SELECTIVE INHIBITOR OF HERPES-SIMPLEX THYMIDINE KINASE

被引：4
|
作者：
KIM, CU [1 ]
MISCO, PF [1 ]
LUH, BY [1 ]
TERRY, B [1 ]
BISACCHI, G [1 ]
MANSURI, MM [1 ]
机构：
[1] BRISTOL MYERS SQUIBB PHARMACEUT,RES INST,5 RES PKWY,WALLINGFORD,CT 06492
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(00)80020-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of thymidine analogues substituted with alkoxy groups on the C-4 position of the furan ring were synthesized. Among these compounds, the methoxy analogue 9 was the most potent inhibitor of herpes simplex virus type 1 thymidine kinase.
引用
收藏
页码：1571 / 1576
页数：6
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