Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners

被引：21

作者：

Thomopoulos, Costas ^{[1
]}

Michalopoulou, Helena ^{[2
]}

Kasiakogias, Alexandros ^{[3
]}

Kefala, Anna ^{[3
]}

Makris, Thomas ^{[1
]}

机构：

[1] Elena Venizelou Hosp, Dept Cardiol, 2 Elena Venizelou Sqr, Athens 11521, Greece

[2] Metaxa Canc Hosp, Dept Cardiol, Piraeus 18537, Greece

[3] Univ Athens, Hippokrat Hosp, Cardiol Clin 1, Athens 11527, Greece

来源：

INTERNATIONAL JOURNAL OF HYPERTENSION | 2011年 / 2011卷

关键词：

D O I：

10.4061/2011/947246

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Enhanced target organ damage and cardiovascular morbidity represent common issues observed in both resistant hypertension and obstructive sleep apnea. Common pathophysiological features and risk factors justify their coexistence, especially in individuals with increased upper-body adiposity. Impaired sodium handling, sympathetic activation, accelerated arterial stiffening, and impaired cardiorenal hemodynamics contribute to drug-resistant hypertension development in obstructive sleep apnea. Effective CPAP therapy qualifies as an effective "add-on" to the underlying antihypertensive pharmacological therapy, and emerging evidence underlines the favorable effect of mineralocorticoid antagonists on both resistant hypertension and obstructive sleep apnea treatment.

引用

页数：5

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