ON THE MECHANISM OF ANTIEPILEPTIC PEPTIDES APPEARANCE IN THE CEREBROSPINAL-FLUID

被引：3

作者：

SHANDRA, AA

GODLEVSKY, LS

MAZARATI, AM

PANENKO, AV

TKACHENKO, IV

CHIRKOV, YP

机构：

[1] Medical Institute, 270100 Odessa, 2, Narimanov Lane

来源：

BRAIN RESEARCH BULLETIN | 1994年 / 35卷 / 04期

关键词：

CEREBROSPINAL FLUID; ELECTROSHOCK; CEREBELLUM; COLLICULI SUPERIOR; PEPTIDES; PICROTOXIN;

D O I：

10.1016/0361-9230(94)90102-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraventricular injection of cerebrospinal fluid obtained from cats with electroshock seizures resulted in suppression of generalized picrotoxin-induced seizures in rats. Antiepileptic action of cerebrospinal fluid was abolished by partial bilateral midbrain destruction that included the region of colliculi superii. Electrical stimulation of cerebellum in cats with such destructions caused the appearance of a pronase-sensitive antiepileptic substances in cerebrospinal fluid.

引用

页码：285 / 287

页数：3

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