DETERMINATION OF POLYSULFIDES IN BLOOD BY GAS-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：20
|
作者：
KAGE, S
NAGATA, T
KUDO, K
机构：
[1] Department of Forensic Medicine, Faculty of Medicine, Kyushu University, Higashi-ku, Fukuoka, 812, 3-1-1, Maidashi
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 564卷 / 01期
关键词：
D O I：
10.1016/0378-4347(91)80078-Q
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive and simple method to determine polysulphides in human blood, using an extractive alkylation technique and gas chromatography, has been devised. Polysulphides were alkylated with pentafluorobenzyl bromide, and then converted into bis(pentafluorobenzyl)disulphide by desulphuration with potassium cyanide. The disulphide was analysed qualitatively by mass fragmentography and quantitatively by gas chromatography with electron-capture detection. The lower limit of detection was 0.005-mu-mol/ml. Field testing in a suicide case confirmed the validity of the method.
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页码：163 / 169
页数：7
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