A water-insoluble, self-standing cast film of a DNA-lipid complex is prepared by mixing aqueous solutions of both anionic DNAs and cationic amphiphiles at a charge ratio of 1:1. Intercalation behaviours of dye molecules into a cast film of a DNA-lipid complex deposited on a quartz-crystal microbalance (QCM) are followed quantitatively by observing frequency changes of the QCM in an aqueous solution.