The isomerization/chlorination of O,O-dialkyl N,N-dialkyl thiophosphoramidate with phosphorus oxychloride - A new method for synthesis of S-alkyl N,N-dialkyl thiophosphoramidic acid derivatives

被引：10
|
作者：
Tang, CC
Wu, GP
He, SJ
He, ZJ
机构：
[1] Elemento-Organic Chemistry Laboratory, Nankai University, Tianjin 300071, People's
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1995年 / 101卷 / 1-4期
关键词：
thiophosphoramidate; thiophosphorochloridate; isomerization; chlorination;
D O I：
10.1080/10426509508042503
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new convenient method for synthesis of S-alkyl N,N-dialkyl thiophosphoramidic acid derivatives is reported. The chlorination of O,O-dialkyl N,N-dialkyl thiophosphoramidates with phosphorus oxy chloride proceeds with isomerization to give S-alkyl N,N-dialkyl thiophosphoramidochloridates. which react further with various nucleophiles in the presence of base to give the title compounds. However, in the reaction of O,O-diethyl N,N-dimethyl thiophosphoramidate with phosphorus oxychloride, an unexpected exchange between chlorine atom and dimethylamino group is observed.
引用
收藏
页码：91 / 94
页数：4
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