Metabolic syndrome of prediabetic and diabetic subjects in a Bangladeshi population

Background: The metabolic syndrome is a cluster of medical disorder that increases the risk of developing cardiovascular disease and diabetes. Aims and objective: Objective of the study was to determine the metabolic syndrome in prediabetic subjects to know whether this syndrome, which is common in diabetic subjects, appears in earlier stage of the disease. Materials and methods: A group of 17 IFG, 60 IGT, 29 combined IFG-IGT and 68 type 2 DM subjects were studied along with a group of 56 healthy controls. Anthropometric and clinical characteristics were measured using appropriate methods. Serum glucose was measured using glucose-oxidase method; lipid profile by enzymatic-colorimetric method. Results: Waist hip ratio (WHR) was significantly higher in IFG-IGT and type 2 DM subjects. Systolic blood pressure was significantly higher in IFG-IGT and diastolic blood pressure is significantly higher in IGT, IFG-IGT and type 2 DM compared to controls. Fasting serum TG (p = 0.008) and cholesterol (p = 0.001) level was significantly higher in type 2 DM subjects but the values were not significantly different in prediabetic subjects compared to controls. HOMA B% and HOMA S% were significantly lower in DM and IFG-IGT subjects, IFG subjects have also shown significantly lower HOMA B% compared to controls. Conclusion: These results indicate that hypertension, central obesity (WHR) and insulin resistance, three major factors for metabolic syndrome are present in prediabetic condition in a Bangladeshi population. (C) 2009 Diabetes India. Published by Elsevier Ltd. All rights reserved.