CYANIDE INDUCES CA2+-DEPENDENT AND CA2+-INDEPENDENT RELEASE OF GLUTAMATE FROM MOUSE-BRAIN SLICES

被引：43
|
作者：
PATEL, MN [1 ]
ARDELT, BK [1 ]
YIM, GKW [1 ]
ISOM, GE [1 ]
机构：
[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT PHARMACOL & TOXICOL,W LAFAYETTE,IN 47907
来源：
NEUROSCIENCE LETTERS | 1991年 / 131卷 / 01期
关键词：
HISTOTOXIC-HYPOXIA; GLUTAMATE RELEASE; CYANIDE; BRAIN SLICE;
D O I：
10.1016/0304-3940(91)90332-N
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of cyanide-induced histotoxic hypoxia on endogenous glutamate release from mouse cortical, cerebellar and hippocampal slices was studied. Incubation of slices with cyanide over a 30 min period resulted in extracellular accumulation of glutamate which was decreased in the absence of Ca2+ in the incubation media. When glutamate release was continuously monitored by fluorometry, cyanide initiated a rapid release of glutamate. This initital release was found to be independent of extracellular calcium. Depolarizing concentrations of potassium chloride produced a predominantly Ca2+-dependent release. It is concluded that cyanide exposure induced a rapid release of endogenous glutamate mediated by both Ca2+-dependent and Ca2+-independent mechanisms.
引用
收藏
页码：42 / 44
页数：3
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